Reroll your destiny and prove you're the ultimate basement-dweller before Mom finds the kitchen knife.
Which type of item remains in Isaac’s inventory and continuously affects gameplay after pickup?
Passive
After defeating It Lives!, which location besides Sheol becomes accessible as one of Isaac’s two endgame paths?
The Cathedral
Which item is especially useful for surviving Ultra Greedier’s frequent explosive attacks?
Pyromaniac
In the standard early-game route, which chapter ends with Isaac encountering Mom?
The Depths
Which major boss must players defeat for the first time to unlock the character Apollyon?
Mega Satan